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DNA crosslinking and biological activity of a hairpin polyamide–chlorambucil conjugate
A prototype of a novel class of DNA alkylating agents, which combines the DNA crosslinking moiety chlorambucil (Chl) with a sequence-selective hairpin pyrrole–imidazole polyamide ImPy-β-ImPy-γ-ImPy-β-Dp (polyamide 1), was evaluated for its ability to damage DNA and induce biological responses. Polya...
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| Autors principals: | , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Oxford University Press
2003
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC150233/ https://ncbi.nlm.nih.gov/pubmed/12582240 |
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