Unanticipated differences between α- and γ-diaminobutyric acid-linked hairpin polyamide-alkylator conjugates

Hairpin polyamide–chlorambucil conjugates containing an α-diaminobutyric acid (α-DABA) turn moiety are compared to their constitutional isomers containing the well-characterized γ-DABA turn. Although the DNA-binding properties of unconjugated polyamides are similar, the α-DABA conjugates display inc...

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Autors principals: Tsai, Sherry M., Farkas, Michelle E., Chou, C. James, Gottesfeld, Joel M., Dervan, Peter B.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2007
Matèries:
Chemistry
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1802559/
https://ncbi.nlm.nih.gov/pubmed/17170006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkl1025
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