Unanticipated differences between α- and γ-diaminobutyric acid-linked hairpin polyamide-alkylator conjugates

Hairpin polyamide–chlorambucil conjugates containing an α-diaminobutyric acid (α-DABA) turn moiety are compared to their constitutional isomers containing the well-characterized γ-DABA turn. Although the DNA-binding properties of unconjugated polyamides are similar, the α-DABA conjugates display inc...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Tsai, Sherry M., Farkas, Michelle E., Chou, C. James, Gottesfeld, Joel M., Dervan, Peter B.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Oxford University Press 2007
Pynciau:
Chemistry
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC1802559/
https://ncbi.nlm.nih.gov/pubmed/17170006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkl1025
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