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DNA crosslinking and biological activity of a hairpin polyamide–chlorambucil conjugate

A prototype of a novel class of DNA alkylating agents, which combines the DNA crosslinking moiety chlorambucil (Chl) with a sequence-selective hairpin pyrrole–imidazole polyamide ImPy-β-ImPy-γ-ImPy-β-Dp (polyamide 1), was evaluated for its ability to damage DNA and induce biological responses. Polya...

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Detalhes bibliográficos
Main Authors: Wang, Yong-Dong, Dziegielewski, Jaroslaw, Wurtz, Nicholas R., Dziegielewska, Barbara, Dervan, Peter B., Beerman, Terry A.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2003
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC150233/
https://ncbi.nlm.nih.gov/pubmed/12582240
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