Repression of Smoothened by Patched-Dependent (Pro-)Vitamin D3 Secretion

The developmentally important hedgehog (Hh) pathway is activated by binding of Hh to patched (Ptch1), releasing smoothened (Smo) and the downstream transcription factor glioma associated (Gli) from inhibition. The mechanism behind Ptch1-dependent Smo inhibition remains unresolved. We now show that b...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Bijlsma, Maarten F, Spek, C. Arnold, Zivkovic, Danica, van de Water, Sandra, Rezaee, Farhad, Peppelenbosch, Maikel P
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2006
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC1502141/
https://ncbi.nlm.nih.gov/pubmed/16895439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.0040232
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