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Patched1 and Patched2 inhibit Smoothened non-cell autonomously

Smoothened (Smo) inhibition by Patched (Ptch) is central to Hedgehog (Hh) signaling. Ptch, a proton driven antiporter, is required for Smo inhibition via an unknown mechanism. Hh ligand binding to Ptch reverses this inhibition and activated Smo initiates the Hh response. To determine whether Ptch in...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Roberts, Brock, Casillas, Catalina, Alfaro, Astrid C, Jägers, Carina, Roelink, Henk
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5014547/
https://ncbi.nlm.nih.gov/pubmed/27552050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.17634
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