Response to inhibition of smoothened in diverse epithelial cancer cells that lack smoothened or patched 1 mutations

Hedgehog (HH) pathway Smoothened (Smo) inhibitors are active against Gorlin syndrome-associated basal cell carcinoma (BCC) and medulloblastoma where Patched (Ptch) mutations occur. We interrogated 705 epithelial cancer cell lines for growth response to the Smo inhibitor cyclopamine and for expressed...

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Main Authors: GALIMBERTI, FABRIZIO, BUSCH, ALEXANDER M., CHINYENGETERE, FADZAI, MA, TIAN, SEKULA, DAVID, MEMOLI, VINCENT A., DRAGNEV, KONSTANTIN H., LIU, FANG, JOHNSON, KEVIN C., GUO, YONGLI, FREEMANTLE, SARAH J., ANDREW, ANGELINE S., GRENINGER, PATRICIA, ROBBINS, DAVID J., SETTLEMAN, JEFF, BENES, CYRIL, DMITROVSKY, ETHAN
Formato: Artigo
Idioma:Inglês
Publicado em: D.A. Spandidos 2012
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3583816/
https://ncbi.nlm.nih.gov/pubmed/22923130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ijo.2012.1599
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