Blockade of the Ubiquitin Protease UBP43 Destabilizes the Transcription Factor PML/RARα and Inhibits Growth of Acute Promyelocytic Leukemia

New treatments for acute promyelocytic leukemia (APL) are needed. APL cell treatment with all-trans-retinoic acid (RA) degrades the chimeric, dominant negative-acting transcription factor PML/RARα, which is generated by chromosomal translocation. The E1-like ubiquitin-activating enzyme UBE1L associa...

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Detalhes bibliográficos
Main Authors: Guo, Yongli, Dolinko, Andrey V., Chinyengetere, Fadzai, Stanton, Bruce, Bomberger, Jennifer M., Demidenko, Eugene, Zhou, Da-Cheng, Gallagher, Robert, Ma, Tian, Galimberti, Fabrizio, Liu, Xi, Sekula, David, Freemantle, Sarah, Dmitrovsky, Ethan
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2999664/
https://ncbi.nlm.nih.gov/pubmed/20935222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-1100
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