UBE1L is a retinoid target that triggers PML/RARα degradation and apoptosis in acute promyelocytic leukemia

All-trans-retinoic acid (RA) treatment induces remissions in acute promyelocytic leukemia (APL) cases expressing the t(15;17) product, promyelocytic leukemia (PML)/RA receptor α (RARα). Microarray analyses previously revealed induction of UBE1L (ubiquitin-activating enzyme E1-like) after RA treatmen...

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Autori principali: Kitareewan, Sutisak, Pitha-Rowe, Ian, Sekula, David, Lowrey, Christopher H., Nemeth, Michael J., Golub, Todd R., Freemantle, Sarah J., Dmitrovsky, Ethan
Natura: Artigo
Lingua:Inglês
Pubblicazione: The National Academy of Sciences 2002
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC122605/
https://ncbi.nlm.nih.gov/pubmed/11891284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.052011299
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