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Patched1 and Patched2 inhibit Smoothened non-cell autonomously
Smoothened (Smo) inhibition by Patched (Ptch) is central to Hedgehog (Hh) signaling. Ptch, a proton driven antiporter, is required for Smo inhibition via an unknown mechanism. Hh ligand binding to Ptch reverses this inhibition and activated Smo initiates the Hh response. To determine whether Ptch in...
Gorde:
| Argitaratua izan da: | eLife |
|---|---|
| Egile Nagusiak: | , , , , |
| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
eLife Sciences Publications, Ltd
2016
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5014547/ https://ncbi.nlm.nih.gov/pubmed/27552050 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.17634 |
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