Smoothened-dependent and -independent pathways in mammalian noncanonical Hedgehog signaling

Hedgehog proteins are pivotal morphogens acting through a canonical pathway involving first activation of ligand binding to Patched followed by alleviation of Smoothened receptor inhibition, leading to activation of Gli transcription factors. Noncanonical Hedgehog signaling remains poorly characteri...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Faria, Alessandra V. de S., Akyala, Adamu Ishaku, Parikh, Kaushal, Brüggemann, Lois W., Spek, C. Arnold, Cao, Wanlu, Bruno, Marco J., Bijlsma, Maarten F., Fuhler, Gwenny M., Peppelenbosch, Maikel P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2019
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6597826/
https://ncbi.nlm.nih.gov/pubmed/30992365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.007956
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