Internal ribosome entry sequence-mediated translation initiation triggers nonsense-mediated decay

In eukaryotes, a surveillance pathway known as nonsense-mediated decay (NMD) regulates the abundance of messenger RNAs containing premature termination codons (PTCs). In mammalian cells, it has been asserted that the NMD-relevant first round of translation is special and involves initiation by a spe...

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Bibliografiske detaljer
Main Authors: Holbrook, Jill A, Neu-Yilik, Gabriele, Gehring, Niels H, Kulozik, Andreas E, Hentze, Matthias W
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2006
Fag:
Scientific Report
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1500827/
https://ncbi.nlm.nih.gov/pubmed/16799467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.embor.7400721
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