Splicing and 3′ end formation in the definition of nonsense-mediated decay-competent human β-globin mRNPs

Premature translation termination codons are common causes of genetic disorders. mRNAs with such mutations are degraded by a surveillance mechanism termed nonsense-mediated decay (NMD), which represents a phylogenetically widely conserved post-transcriptional mechanism for the quality control of gen...

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Detalhes bibliográficos

Publicado no:	EMBO J
Principais autores:	Neu-Yilik, Gabriele, Gehring, Niels H., Thermann, Rolf, Frede, Ute, Hentze, Matthias W., Kulozik, Andreas E.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Publishing Group 2001
Assuntos:	Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC133467/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11157759/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/20.3.532
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