Splicing and 3′ end formation in the definition of nonsense-mediated decay-competent human β-globin mRNPs

Premature translation termination codons are common causes of genetic disorders. mRNAs with such mutations are degraded by a surveillance mechanism termed nonsense-mediated decay (NMD), which represents a phylogenetically widely conserved post-transcriptional mechanism for the quality control of gen...

Full description

Saved in:
Bibliographic Details
Main Authors: Neu-Yilik, Gabriele, Gehring, Niels H., Thermann, Rolf, Frede, Ute, Hentze, Matthias W., Kulozik, Andreas E.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2001
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC133467/
https://ncbi.nlm.nih.gov/pubmed/11157759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/20.3.532
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items