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Decreased embryonic retinoic acid synthesis results in a DiGeorge syndrome phenotype in newborn mice

Retinoic acid (RA), the active derivative of vitamin A, is involved in various developmental and homeostatic processes. To define whether certain developmental events are particularly sensitive to a decrease in embryonic RA levels, we generated mice bearing a hypomorphic allele of the RA-synthesizin...

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Detalles Bibliográficos
Main Authors: Vermot, Julien, Niederreither, Karen, Garnier, Jean-Marie, Chambon, Pierre, Dollé, Pascal
Formato: Artigo
Idioma:Inglês
Publicado: The National Academy of Sciences 2003
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC149907/
https://ncbi.nlm.nih.gov/pubmed/12563036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0437920100
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