Active-Site Residues of Escherichia coli DNA Gyrase Required in Coupling ATP Hydrolysis to DNA Supercoiling and Amino Acid Substitutions Leading to Novobiocin Resistance

DNA gyrase is a bacterial type II topoisomerase which couples the free energy of ATP hydrolysis to the introduction of negative supercoils into DNA. Amino acids in proximity to bound nonhydrolyzable ATP analog (AMP · PNP) or novobiocin in the gyrase B (GyrB) subunit crystal structures were examined...

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Publicat a:	Antimicrob Agents Chemother
Autors principals:	Gross, Christian H., Parsons, Jonathan D., Grossman, Trudy H., Charifson, Paul S., Bellon, Steven, Jernee, James, Dwyer, Maureen, Chambers, Stephen P., Markland, William, Botfield, Martyn, Raybuck, Scott A.
Format:	Artigo
Idioma:	Inglês
Publicat:	American Society for Microbiology (ASM) 2003
Matèries:	Mechanisms of Resistance
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC149296/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12604539/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.47.3.1037-1046.2003
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