Active-Site Residues of Escherichia coli DNA Gyrase Required in Coupling ATP Hydrolysis to DNA Supercoiling and Amino Acid Substitutions Leading to Novobiocin Resistance

DNA gyrase is a bacterial type II topoisomerase which couples the free energy of ATP hydrolysis to the introduction of negative supercoils into DNA. Amino acids in proximity to bound nonhydrolyzable ATP analog (AMP · PNP) or novobiocin in the gyrase B (GyrB) subunit crystal structures were examined...

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-д хэвлэсэн:	Antimicrob Agents Chemother
Үндсэн зохиолчид:	Gross, Christian H., Parsons, Jonathan D., Grossman, Trudy H., Charifson, Paul S., Bellon, Steven, Jernee, James, Dwyer, Maureen, Chambers, Stephen P., Markland, William, Botfield, Martyn, Raybuck, Scott A.
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	American Society for Microbiology (ASM) 2003
Нөхцлүүд:	Mechanisms of Resistance
Онлайн хандалт:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC149296/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12604539/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.47.3.1037-1046.2003
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