Topoisomerase Targeting with and Resistance to Gemifloxacin in Staphylococcus aureus

Gemifloxacin, a novel quinolone with potent activity against Staphylococcus aureus, was 8- to 16-fold more active against wild-type S. aureus than ciprofloxacin. The two- to fourfold increase in the MIC of gemifloxacin in genetically defined grlBA mutants and the twofold increase in a single gyrA mu...

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Veröffentlicht in:	Antimicrob Agents Chemother
Hauptverfasser:	Ince, Dilek, Zhang, Xiamei, Silver, L. Christine, Hooper, David C.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 2003
Schlagworte:	Mechanisms of Resistance
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC149033/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12499202/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.47.1.274-282.2003
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