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Effects of Mutations in GrlA of Topoisomerase IV from Staphylococcus aureus on Quinolone and Coumarin Activity

The grlA genes of Staphylococcus aureus ISP794 (wild type), MT5224c4 (grlA [Phe-80]), MT5224c2 (grlA [Pro-116]), and MT111 (grlA [Glu-116]) were cloned in pSK950, a shuttle vector, and introduced into S. aureus strains derived from strain RN4220. The mutations at position 116 of GrlA (Ala→Pro or Glu...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Principais autores: Fournier, Bénédicte, Hooper, David C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 1998
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC105875/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9687416/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.42.8.2109
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