p14(ARF) Activates a Tip60-Dependent and p53-Independent ATM/ATR/CHK Pathway in Response to Genotoxic Stress

p14(ARF) is a tumor suppressor that controls a well-described p53/Mdm2-dependent checkpoint in response to oncogenic signals. Here, new insights into the tumor-suppressive function of p14(ARF) are provided. We previously showed that p14(ARF) can induce a p53-independent G(2) cell cycle arrest. In th...

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Détails bibliographiques
Auteurs principaux: Eymin, Béatrice, Claverie, Paule, Salon, Caroline, Leduc, Camille, Col, Edwige, Brambilla, Elisabeth, Khochbin, Saadi, Gazzeri, Sylvie
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2006
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Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1489086/
https://ncbi.nlm.nih.gov/pubmed/16705183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.02240-05
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