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Regulation of NF-κB and p53 through activation of ATR and Chk1 by the ARF tumour suppressor
The ARF tumour suppressor is a central component of the cellular defence against oncogene activation. In addition to activating p53 through binding Mdm2, ARF possesses other functions, including an ability to repress the transcriptional activity of the antiapoptotic RelA(p65) NF-κB subunit. Here we...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC556410/ https://ncbi.nlm.nih.gov/pubmed/15775976 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600608 |
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