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IKK and NF-κB-mediated regulation of Claspin impacts on ATR checkpoint function
In response to replication stress, Claspin mediates the phosphorylation and activation of Chk1 by ATR. Claspin is not only necessary for the propagation of the DNA-damage signal, but its destruction by the ubiquitin–proteosome pathway is required to allow the cell to continue the cell cycle allowing...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2944043/ https://ncbi.nlm.nih.gov/pubmed/20657549 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2010.171 |
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