Fitness Comparison of Thymidine Analog Resistance Pathways in Human Immunodeficiency Virus Type 1

Resistance to zidovudine (ZDV) results from thymidine analog resistance mutations (TAMs) at human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) codons 41, 67, 70, 210, 215, and 219. Two mutations are possible at codon 215: Y or F. Whereas T215Y occurs alone or with M41L and L210W...

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Detalhes bibliográficos
Main Authors: Hu, Zixin, Giguel, Françoise, Hatano, Hiroyu, Reid, Patrick, Lu, Jing, Kuritzkes, Daniel R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2006
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1489059/
https://ncbi.nlm.nih.gov/pubmed/16809307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02747-05
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