Comparison of the Phosphorylation of 4′-Ethynyl 2′,3′-Dihydro-3′-Deoxythymidine with That of Other Anti-Human Immunodeficiency Virus Thymidine Analogs

Thymidine analogs, including 3′-azido-3′-deoxythymidine (AZT) and 2′,3′-dideoxy-3′-deoxythymidine (D4T), are important antiretroviral agents. To exert antiretroviral activity, these analogs undergo a stepwise phosphorylation intracellularly to the active triphosphate metabolites. We previously repor...

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Main Authors: Hsu, Chih-Hung, Hu, Rong, Dutschman, Ginger E., Yang, Guangwei, Krishnan, Preethi, Tanaka, Hiromichi, Baba, Masanori, Cheng, Yung-Chi
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology (ASM) 2007
Assuntos:
Antiviral Agents
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1855562/
https://ncbi.nlm.nih.gov/pubmed/17353236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01432-06
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