Novel 4′-Substituted Stavudine Analog with Improved Anti-Human Immunodeficiency Virus Activity and Decreased Cytotoxicity

The antiviral drug 2′,3′-didehydro-3′-deoxythymidine (D4T; also know as stavudine and Zerit), which is used against human immunodeficiency virus (HIV), causes delayed toxicity (peripheral neuropathy) in long-term use. After examining a series of 2′,3′-didehydro-3′-deoxy-4′-substituted thymidine (4′-...

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Detalhes bibliográficos
Main Authors: Dutschman, Ginger E., Grill, Susan P., Gullen, Elizabeth A., Haraguchi, Kazuhiro, Takeda, Shingo, Tanaka, Hiromichi, Baba, Masanori, Cheng, Yung-Chi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC400579/
https://ncbi.nlm.nih.gov/pubmed/15105115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.48.5.1640-1646.2004
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