Relative Replicative Fitness of Human Immunodeficiency Virus Type 1 Mutants Resistant to Enfuvirtide (T-20)

Resistance to enfuvirtide (ENF; T-20), a fusion inhibitor of human immunodeficiency virus type 1 (HIV-1), is conferred by mutations in the first heptad repeat of the gp41 ectodomain. The replicative fitness of recombinant viruses carrying ENF resistance mutations was studied in growth competition as...

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Bibliographic Details
Main Authors: Lu, Jing, Sista, Prakash, Giguel, Françoise, Greenberg, Michael, Kuritzkes, Daniel R.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2004
Subjects:
Vaccines and Antiviral Agents
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC387671/
https://ncbi.nlm.nih.gov/pubmed/15078945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.9.4628-4637.2004
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