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Both Spike and Background Genes Contribute to Murine Coronavirus Neurovirulence

Various strains of mouse hepatitis virus (MHV) exhibit different pathogenic phenotypes. Infection with the A59 strain of MHV induces both encephalitis and hepatitis, while the highly neurovirulent JHM strain induces a fatal encephalitis with little, if any, hepatitis. The pathogenic phenotype for ea...

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Autors principals: Iacono, Kathryn T., Kazi, Lubna, Weiss, Susan R.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2006
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1489045/
https://ncbi.nlm.nih.gov/pubmed/16809289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00432-06
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