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Contributions of the Viral Genetic Background and a Single Amino Acid Substitution in an Immunodominant CD8(+) T-Cell Epitope to Murine Coronavirus Neurovirulence

The immunodominant CD8(+) T-cell epitope of a highly neurovirulent strain of mouse hepatitis virus (MHV), JHM, is thought to be essential for protection against virus persistence within the central nervous system. To test whether abrogation of this H-2D(b)-restricted epitope, located within the spik...

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Detalles Bibliográficos
Main Authors: MacNamara, Katherine C., Chua, Ming Ming, Phillips, Joanna J., Weiss, Susan R.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2005
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1168726/
https://ncbi.nlm.nih.gov/pubmed/15994805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.14.9108-9118.2005
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