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Contributions of the Viral Genetic Background and a Single Amino Acid Substitution in an Immunodominant CD8(+) T-Cell Epitope to Murine Coronavirus Neurovirulence
The immunodominant CD8(+) T-cell epitope of a highly neurovirulent strain of mouse hepatitis virus (MHV), JHM, is thought to be essential for protection against virus persistence within the central nervous system. To test whether abrogation of this H-2D(b)-restricted epitope, located within the spik...
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| Главные авторы: | , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society for Microbiology
2005
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1168726/ https://ncbi.nlm.nih.gov/pubmed/15994805 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.14.9108-9118.2005 |
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