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Effects of an Epitope-Specific CD8(+) T-Cell Response on Murine Coronavirus Central Nervous System Disease: Protection from Virus Replication and Antigen Spread and Selection of Epitope Escape Mutants

Both CD4(+) and CD8(+) T cells are required for clearance of the murine coronavirus mouse hepatitis virus (MHV) during acute infection. We investigated the effects of an epitope-specific CD8(+) T-cell response on acute infection of MHV, strain A59, in the murine CNS. Mice with CD8(+) T cells specifi...

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Autori principali: Chua, Ming Ming, MacNamara, Katherine C., San Mateo, Lani, Shen, Hao, Weiss, Susan R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2004
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC321401/
https://ncbi.nlm.nih.gov/pubmed/14722270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.3.1150-1159.2004
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