The antiviral enzymes PKR and RNase L suppress gene expression from viral and non-viral based vectors.

Expression of transfected genes is shown to be suppressed by two intracellular enzymes, RNase L and protein kinase PKR, which function in interferon-treated cells to restrict viral replication. RNase L(-/-) or PKR(-/-) murine embryonic fibroblasts produced enhanced levels of protein from transfected...

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Detalhes bibliográficos
Main Authors: Terenzi, F, deVeer, M J, Ying, H, Restifo, N P, Williams, B R, Silverman, R H
Formato: Artigo
Idioma:Inglês
Publicado em: 1999
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC148718/
https://ncbi.nlm.nih.gov/pubmed/10536144
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