Inhibition of RNase L and RNA-dependent Protein Kinase (PKR) by Sunitinib Impairs Antiviral Innate Immunity

RNase L and RNA-dependent protein kinase (PKR) are effectors of the interferon antiviral response that share homology in their pseudokinase and protein kinase domains, respectively. Sunitinib is an orally available, ATP-competitive inhibitor of VEGF and PDGF receptors used clinically to suppress ang...

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Detalhes bibliográficos
Main Authors: Jha, Babal Kant, Polyakova, Irina, Kessler, Patricia, Dong, Beihua, Dickerman, Benjamin, Sen, Ganes C., Silverman, Robert H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Microbiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3143594/
https://ncbi.nlm.nih.gov/pubmed/21636578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.253443
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