Small-molecule activators of RNase L with broad-spectrum antiviral activity

RNase L, a principal mediator of innate immunity to viral infections in higher vertebrates, is required for a complete IFN antiviral response against certain RNA stranded viruses. dsRNA produced during viral infections activates IFN-inducible synthetases that produce 5′-phosphorylated, 2′,5′-oligoad...

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Main Authors: Thakur, Chandar S., Jha, Babal Kant, Dong, Beihua, Das Gupta, Jaydip, Silverman, Kenneth M., Mao, Hongxia, Sawai, Hiro, Nakamura, Akiko O., Banerjee, Amiya K., Gudkov, Andrei, Silverman, Robert H.
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2007
主題:
Biological Sciences
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1877983/
https://ncbi.nlm.nih.gov/pubmed/17535916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0700590104
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