Small-molecule activators of RNase L with broad-spectrum antiviral activity

RNase L, a principal mediator of innate immunity to viral infections in higher vertebrates, is required for a complete IFN antiviral response against certain RNA stranded viruses. dsRNA produced during viral infections activates IFN-inducible synthetases that produce 5′-phosphorylated, 2′,5′-oligoad...

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Hauptverfasser: Thakur, Chandar S., Jha, Babal Kant, Dong, Beihua, Das Gupta, Jaydip, Silverman, Kenneth M., Mao, Hongxia, Sawai, Hiro, Nakamura, Akiko O., Banerjee, Amiya K., Gudkov, Andrei, Silverman, Robert H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2007
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1877983/
https://ncbi.nlm.nih.gov/pubmed/17535916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0700590104
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