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Backtracking by single RNA polymerase molecules observed at near-base-pair resolution
Escherichia coli RNA polymerase (RNAP) synthesizes RNA with remarkable fidelity in vivo1. Its low error rate may be achieved by means of a ‘proofreading’ mechanism comprised of two sequential events. The first event (backtracking) involves a transcriptionally upstream motion of RNAP through several...
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| Auteurs principaux: | , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2003
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1483218/ https://ncbi.nlm.nih.gov/pubmed/14634670 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature02191 |
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