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Direct observation of base-pair stepping by RNA polymerase
During transcription, RNA polymerase (RNAP) moves processively along a DNA template, creating a complementary RNA. Here we present the development of an ultra-stable optical trapping system with ångström-level resolution, which we used to monitor transcriptional elongation by single molecules of Esc...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1356566/ https://ncbi.nlm.nih.gov/pubmed/16284617 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature04268 |
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