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Backtracking by single RNA polymerase molecules observed at near-base-pair resolution

Escherichia coli RNA polymerase (RNAP) synthesizes RNA with remarkable fidelity in vivo1. Its low error rate may be achieved by means of a ‘proofreading’ mechanism comprised of two sequential events. The first event (backtracking) involves a transcriptionally upstream motion of RNAP through several...

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Bibliografski detalji
Glavni autori: Shaevitz, Joshua W., Abbondanzieri, Elio A., Landick, Robert, Block, Steven M.
Format: Artigo
Jezik:Inglês
Izdano: 2003
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1483218/
https://ncbi.nlm.nih.gov/pubmed/14634670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature02191
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