Targeted gene repair directed by the chimeric RNA/DNA oligonucleotide in a mammalian cell-free extract.

Chimeric oligonucleotides consisting of RNA and DNA residues have been shown to catalyze site-directed genetic alteration in mammalian cells both in vitro and in vivo. Since the frequency of these events appears to be logs higher than the rates of gene targeting, a process involving homologous recom...

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Опубликовано в::	Nucleic Acids Res
Главные авторы:	Cole-Strauss, A, Gamper, H, Holloman, W K, Muñoz, M, Cheng, N, Kmiec, E B
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Oxford University Press 1999
Предметы:	Research Article
Online-ссылка:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC148319/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9973621/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/27.5.1323
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