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Targeted gene repair directed by the chimeric RNA/DNA oligonucleotide in a mammalian cell-free extract.

Chimeric oligonucleotides consisting of RNA and DNA residues have been shown to catalyze site-directed genetic alteration in mammalian cells both in vitro and in vivo. Since the frequency of these events appears to be logs higher than the rates of gene targeting, a process involving homologous recom...

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Bibliografische gegevens
Hoofdauteurs: Cole-Strauss, A, Gamper, H, Holloman, W K, Muñoz, M, Cheng, N, Kmiec, E B
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 1999
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC148319/
https://ncbi.nlm.nih.gov/pubmed/9973621
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