Targeted gene repair directed by the chimeric RNA/DNA oligonucleotide in a mammalian cell-free extract.

Chimeric oligonucleotides consisting of RNA and DNA residues have been shown to catalyze site-directed genetic alteration in mammalian cells both in vitro and in vivo. Since the frequency of these events appears to be logs higher than the rates of gene targeting, a process involving homologous recom...

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Detalhes bibliográficos

Publicado no:	Nucleic Acids Res
Principais autores:	Cole-Strauss, A, Gamper, H, Holloman, W K, Muñoz, M, Cheng, N, Kmiec, E B
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Oxford University Press 1999
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC148319/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9973621/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/27.5.1323
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