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A New Alkylation-Elimination Method for Synthesis of Antiviral Fluoromethylenecyclopropane Analogues of Nucleosides

A new method for the synthesis of fluoromethylenecyclopropane nucleosides by alkylation-elimination procedure is described. Fluorination of methylenecyclopropane carboxylate 6 gave fluoroester 7. Treatment of 7 with phenylselenenyl bromide afforded the desired ethyl (E)-2-bromomethyl-1-fluoro-2-phen...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Zhou, Shaoman, Zemlicka, Jiri
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2005
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1482787/
https://ncbi.nlm.nih.gov/pubmed/16801980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tet.2005.05.054
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