Phosphatidylinositol 3-kinase mediates activation of ATM by high NaCl and by ionizing radiation: Role in osmoprotective transcriptional regulation

High NaCl causes DNA double-strand breaks and activates the transcription factor, TonEBP/OREBP, resulting in increased transcription of several protective genes, including those involved in accumulation of compatible organic osmolytes. Several kinases are known to contribute to signaling activation...

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Détails bibliographiques
Auteurs principaux: Irarrazabal, Carlos E., Burg, Maurice B., Ward, Stephen G., Ferraris, Joan D.
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2006
Sujets:
Biological Sciences
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1482672/
https://ncbi.nlm.nih.gov/pubmed/16728507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0602911103
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