Mediator of DNA Damage Checkpoint 1 (MDC1) Contributes to High NaCl-Induced Activation of the Osmoprotective Transcription Factor TonEBP/OREBP

BACKGROUND: Hypertonicity, such as induced by high NaCl, increases the activity of the transcription factor TonEBP/OREBP whose target genes increase osmoprotective organic osmolytes and heat shock proteins. METHODOLOGY: We used mass spectrometry to analyze proteins that coimmunoprecipitate with TonE...

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Bibliographic Details
Main Authors: Kunin, Margarita, Dmitrieva, Natalia I., Gallazzini, Morgan, Shen, Rong-Fong, Wang, Guanghui, Burg, Maurice B., Ferraris, Joan D.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2010
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2920327/
https://ncbi.nlm.nih.gov/pubmed/20711462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0012108
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