Phospholipase C-γ1 is involved in signaling the activation by high NaCl of the osmoprotective transcription factor TonEBP/OREBP

High NaCl elevates activity of the osmoprotective transcription factor TonEBP/OREBP by increasing its phosphorylation, transactivating activity, and localization to the nucleus. We investigated the possible role in this activation of phospholipase C-γ1 (PLC-γ1), which has a predicted binding site at...

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Detalhes bibliográficos
Main Authors: Irarrazabal, Carlos E., Gallazzini, Morgan, Schnetz, Michael P., Kunin, Margarita, Simons, Brigitte L., Williams, Chester K., Burg, Maurice B., Ferraris, Joan D.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2009
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2818890/
https://ncbi.nlm.nih.gov/pubmed/20080774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0913415107
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