Mutations that reduce its specific DNA binding inhibit high NaCl-induced nuclear localization of the osmoprotective transcription factor NFAT5

The transcription factor nuclear factor of activated T cell 5 (NFAT5) is activated by the stress of hypertonicity (e.g., high NaCl). Increased expression of NFAT5 target genes causes accumulation of protective organic osmolytes and heat shock proteins. Under normotonic conditions (∼300 mosmol/kgH(2)...

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Hlavní autoři: Izumi, Yuichiro, Li, Jinxi, Villers, Courtney, Hashimoto, Kosuke, Burg, Maurice B., Ferraris, Joan D.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2012
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3492838/
https://ncbi.nlm.nih.gov/pubmed/22992674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00265.2012
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