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Rac1/osmosensing scaffold for MEKK3 contributes via phospholipase C-γ1 to activation of the osmoprotective transcription factor NFAT5
Separate reports that hypertonicity activates p38 via a Rac1–OSM–MEKK3–MKK3–p38 pathway and that p38α contributes to activation of TonEBP/OREBP led us to the hypothesis that Rac1 might activate TonEBP/OREBP via p38. The present studies examine that possibility. High NaCl is hypertonic. We find that...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
National Academy of Sciences
2011
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3141947/ https://ncbi.nlm.nih.gov/pubmed/21712438 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1108107108 |
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