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Restriction beyond the restriction point: mitogen requirement for G(2 )passage

Cell proliferation is dependent on mitogenic signalling. When absent, normal cells cannot pass the G(1 )restriction point, resulting in cell cycle arrest. Passage through the G(1 )restriction point involves inactivation of the retinoblastoma protein family. Consequently, loss of the retinoblastoma p...

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Bibliographic Details
Main Authors: Foijer, Floris, te Riele, Hein
Format: Artigo
Language:Inglês
Published: BioMed Central 2006
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1481568/
https://ncbi.nlm.nih.gov/pubmed/16759363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1747-1028-1-8
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