Loss of Rb proteins causes genomic instability in the absence of mitogenic signaling

Loss of G1/S control is a hallmark of cancer, and is often caused by inactivation of the retinoblastoma pathway. However, mouse embryonic fibroblasts lacking the retinoblastoma genes RB1, p107, and p130 (TKO MEFs) are still subject to cell cycle control: Upon mitogen deprivation, they enter and comp...

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Detalhes bibliográficos
Main Authors: van Harn, Tanja, Foijer, Floris, van Vugt, Marcel, Banerjee, Ruby, Yang, Fentang, Oostra, Anneke, Joenje, Hans, te Riele, Hein
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2010
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2895197/
https://ncbi.nlm.nih.gov/pubmed/20551164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.580710
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