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Anchorage-Independent Growth of Pocket Protein-Deficient Murine Fibroblasts Requires Bypass of G(2) Arrest and Can Be Accomplished by Expression of TBX2
Mouse embryonic fibroblasts (MEFs) deficient for pocket proteins (i.e., pRB/p107-, pRB/p130-, or pRB/p107/p130-deficient MEFs) have lost proper G(1) control and are refractory to Ras(V12)-induced senescence. However, pocket protein-deficient MEFs expressing Ras(V12) were unable to exhibit anchorage-...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology (ASM)
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2593436/ https://ncbi.nlm.nih.gov/pubmed/18936168 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00313-08 |
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