An inhibitor of tau hyperphosphorylation prevents severe motor impairments in tau transgenic mice

An orally bioavailable and blood–brain barrier penetrating analog of the kinase inhibitor K252a was able to prevent the typical motor deficits in the tau (P301L) transgenic mouse model (JNPL3) and markedly reduce soluble aggregated hyperphosphorylated tau. However, neurofibrillary tangle counts were...

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Bibliographic Details
Main Authors: Le Corre, Sylvie, Klafki, Hans W., Plesnila, Nikolaus, Hübinger, Gabriele, Obermeier, Axel, Sahagún, Heidi, Monse, Barbara, Seneci, Pierfausto, Lewis, Jada, Eriksen, Jason, Zehr, Cynthia, Yue, Mei, McGowan, Eileen, Dickson, Dennis W., Hutton, Michael, Roder, Hanno M.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2006
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1480465/
https://ncbi.nlm.nih.gov/pubmed/16769887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0602913103
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