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An inhibitor of tau hyperphosphorylation prevents severe motor impairments in tau transgenic mice
An orally bioavailable and blood–brain barrier penetrating analog of the kinase inhibitor K252a was able to prevent the typical motor deficits in the tau (P301L) transgenic mouse model (JNPL3) and markedly reduce soluble aggregated hyperphosphorylated tau. However, neurofibrillary tangle counts were...
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| 主要な著者: | , , , , , , , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
2006
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1480465/ https://ncbi.nlm.nih.gov/pubmed/16769887 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0602913103 |
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