An inhibitor of tau hyperphosphorylation prevents severe motor impairments in tau transgenic mice

An orally bioavailable and blood–brain barrier penetrating analog of the kinase inhibitor K252a was able to prevent the typical motor deficits in the tau (P301L) transgenic mouse model (JNPL3) and markedly reduce soluble aggregated hyperphosphorylated tau. However, neurofibrillary tangle counts were...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Le Corre, Sylvie, Klafki, Hans W., Plesnila, Nikolaus, Hübinger, Gabriele, Obermeier, Axel, Sahagún, Heidi, Monse, Barbara, Seneci, Pierfausto, Lewis, Jada, Eriksen, Jason, Zehr, Cynthia, Yue, Mei, McGowan, Eileen, Dickson, Dennis W., Hutton, Michael, Roder, Hanno M.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2006
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1480465/
https://ncbi.nlm.nih.gov/pubmed/16769887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0602913103
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados