An inhibitor of tau hyperphosphorylation prevents severe motor impairments in tau transgenic mice

An orally bioavailable and blood–brain barrier penetrating analog of the kinase inhibitor K252a was able to prevent the typical motor deficits in the tau (P301L) transgenic mouse model (JNPL3) and markedly reduce soluble aggregated hyperphosphorylated tau. However, neurofibrillary tangle counts were...

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Main Authors: Le Corre, Sylvie, Klafki, Hans W., Plesnila, Nikolaus, Hübinger, Gabriele, Obermeier, Axel, Sahagún, Heidi, Monse, Barbara, Seneci, Pierfausto, Lewis, Jada, Eriksen, Jason, Zehr, Cynthia, Yue, Mei, McGowan, Eileen, Dickson, Dennis W., Hutton, Michael, Roder, Hanno M.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2006
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1480465/
https://ncbi.nlm.nih.gov/pubmed/16769887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0602913103
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