Dehydromonocrotaline generates sequence-selective N-7 guanine alkylation and heat and alkali stable multiple fragment DNA crosslinks.

Monocrotaline is a pyrrolizidine alkaloid known to cause toxicity in humans and animals. Its mechanism of biological action is still unclear although DNA crosslinking has been suggested to a play a role in its activity. In this study we found that an active metabolite of monocrotaline, dehydromonocr...

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Dades bibliogràfiques

Publicat a:	Nucleic Acids Res
Autors principals:	Pereira, T N, Webb, R I, Reilly, P E, Seawright, A A, Prakash, A S
Format:	Artigo
Idioma:	Inglês
Publicat:	Oxford University Press 1998
Matèries:	Research Article
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC147994/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9826770/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/26.23.5441
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