Dehydromonocrotaline generates sequence-selective N-7 guanine alkylation and heat and alkali stable multiple fragment DNA crosslinks.

Monocrotaline is a pyrrolizidine alkaloid known to cause toxicity in humans and animals. Its mechanism of biological action is still unclear although DNA crosslinking has been suggested to a play a role in its activity. In this study we found that an active metabolite of monocrotaline, dehydromonocr...

全面介紹

書目詳細資料

發表在:	Nucleic Acids Res
Principais autores:	Pereira, T N, Webb, R I, Reilly, P E, Seawright, A A, Prakash, A S
格式:	Artigo
語言:	Inglês
出版:	Oxford University Press 1998
主題:	Research Article
在線閱讀:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC147994/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9826770/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/26.23.5441
標簽:	添加標簽 沒有標簽, 成為第一個標記此記錄!